Uncovering the Hidden Antibiotic Potential of Cannabis

Biofilm CBG Cannabigerol

Uncovering the Hidden Antibiotic Potential of Cannabis

As the spread of antimicrobial resistance continues to be a priority health concern worldwide researchers from McMaster University (Canada) identified an antibacterial compound in the cannabis plants that could serve as a lead for new drug development.

CBG – Cannnabigerol potential benefits

They found that the cannabinoid, cannabigerol (CBG) is antibacterial and also proved effective in mice against a resilient family of bacteria known as methicillin-resistant Staphylococcus aureus (MRSA).

According to Eric Brown ( professor of biochemistry and biomedical sciences at McMaster) 18 available cannabinoids were investigated in the study and all showed some antibiotic activity.

The most promising activity was found in their non-psychoactive cannabinoid CBG. By targeting the cell membrane of the bacteria CBG prevented the bacteria to form biofilm, which are communities of microorganisms that attach to each other and to surfaces; and it destroyed preformed biofilms and cells resistant to antibiotics.

Brown states that “CBG proved to be marvellous at tackling pathogenic bacteria,” and that “The findings suggest real therapeutic potential for cannabinoids as antibiotics.”

Since the legalization of marijuana in Canada 2 years ago the lab has been studying the antibiotic potential of cannabinoids. Brown addresses the stigma that has been to the research of cannabinoids, but with the increasing anecdotal evidence of the medicinal use of cannabis this stigma is now waning. The next steps are to working on making the compound better, that means that it will be more specific to the bacteria and will have a lower chance of toxicity.

Link to full report:

 https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.9b00419#

Sources:

https://www.sciencedaily.com/releases/2020/02/200226131325.htm
https://brighterworld.mcmaster.ca/articles/mcmaster-researchers-uncover-hidden-antibiotic-potential-of-cannabis/
https://www.drugtargetreview.com/news/56606/antibacterial-cannabinoid-compound-identified-by-researchers/

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