Bulk CBD Isolate

Wholesale CBD Isolate Bulk | 99% Pure Cannabidiol | CBD Isolate API

CBD Oil Europe can supply wholesale CBD Isolate in bulk quantities at the most competitive prices in Europe. Our longstanding partners manufacture CBD Isolate for cosmetics, vape and pharmaceutical purposes. Our 99% pure cannabidiol crystals are produced from European certified hemp cultivars and are available in both crystalline and powder form. If you need a reliable regular supply of CBD isolate for your product formulations we can meet your needs. Contact us today to discuss your requirements.

We wrote this article so you have an in depth understanding of this product, how it is manufactured and how it can be used.

What is 99% pure cannabidiol?

CBD isolate is Cannabidiol in its purest form, produced by isolating the natural CBD from all the other compounds found in the hemp plant. This creates a concentrated single molecule 99% pure cannabidiol product that can be used on it’s own or added as an ingredient in any custom formulation you choose.

Chemistry & Properties of Cannabidiol

Cannabidiol on Pubchem

Pubchem cannabidiol

International Nonproprietary Name (INN)

Chemical Abstract Service (CAS) Registry Number


Chemical Name

IUPAC Name: 2-[(6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1- yl]-5-pentylbenzene-1,3-diol

Other Chemical Names:

CBD; 2-[1R-3-methyl-6R-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3- benzenediol;

Molecular Formula: C21H30O2
Molecular Weight: 314.469 g/mol

Chemical Properties of Cannabidiol

Melting point: 62-63°C
Boiling point: 160-180°C
Solubility: approx. 23.6 mg/mL in DSMO and ethanol

Cannabidiol is an cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4. It has a role as a plant metabolite. It is a member of resorcinols, an olefinic compound and a phytocannabinoid.

cannabidiol CBD isolate molecule

99+% Pure CBD Isolate Powder from European Hemp

Our CBD isolate is extracted from the mature stalks and stems & flowers of European certified hemp plants. Made from NON-GMO, PESTICIDE FREE, CO2 Extracted Industrial Hemp oil. This product comes in the Crystalline (Powdered) form:  ingredients: Anhydrous hemp oil, no other active ingredients

CBD Isolate Extraction Methods

There are a variety of methods to produce CBD Isolate from botanical material. The most common for small scale producers involve a 2 or 3 step process:

    • CO2 extraction and winterization
    • Open ethanol wash with vacuum after-purge
    • Ethanol extraction and winterization

To further refine the extract, and to isolate the CBD, the extract goes through Short Path Distillation. This works by heating the extract so each compound is separated because each one has a different boiling point. This way the different compounds can be completely separated.

Botanical CBD Isolate Manufacturers

CBD Oil Europe partner with several botanical CBD Isolate manufacturers. We offer botanical extracts from industrial hemp, these are sometimes also called CBD Distillate resulting in a THC-free CBD Isolate.

No residual solvents. Our products don’t have any residual solvents which is a common issue with other CBD isolates.
Purity. 99% Pure CBD Isolate derived from European-grown industrial hemp.
Color. Pure white. High-quality isolate should sparkle like fresh snow.

Industrial chromatography to separate CBD Isolate

Most industrial production methods use a technique called chromatography.

Chromatography is a laboratory technique for the separation of a mixture. The mixture is dissolved in a fluid called the mobile phase, which carries it through a structure holding another material called the stationary phase. The various constituents of the mixture travel at different speeds, causing them to separate.

Simulated moving bed chromatography

Simulated moving bed (SMB) chromatography SMB chromatography allows separation and purification of one or simultaneously two desired product compounds, the stronger adsorbing compound is obtained as the extract and the weaker adsorbing compound is obtained as the raffinate.

By subjecting the desired cannabinoid compounds which are contained in the extract to further extraction steps, impurities can be removed.

In particular, organic compounds, which may be present from the synthetic step such as starting materials or side products of the synthesis can be removed to a degree such that they are present in an total amount of less than 100 ppm. The extraction agent may be any substance selected from the group consisting of cyclohexane, heptane and other oxygen free hydrocarbons.

This process is described in more detail here: Method for purifying cannabinoid compounds

Centrifugal partition chromatography

Centrifugal partition chromatography (CPC) CPC technology employs a silica-free liquid-liquid chromatography (LLC) column and can be carried out in batch or continuous mode. CPC can be used to purify CBD from crude extracts of Cannabis in just one step

CPC 250 Purification of cannabidiol from cannabis sativa

Synthetic manufacture of CBD Isolate

There are also ways to synthetically manufacture CBD isolate using chemical processes. Synthetic forms of cannabidiol are commercially available (e.g. from Sigma Corp.). However the costs involved in synthetic methods are prohibitive for practical pharmaceutical application

E-mentha-diene-l-01 with olivetol

The condensation of (+)-e-mentha-diene-l-01 with olivetol in the presence of weak acids (oxalic, picric or maleic acid). The isomer obtained in this reaction may be converted to CBD with BF3-etherate by a retro-Friedel- Crafts reaction, followed by recombination. However, with this reagent the reaction proceeds further causing cyclisation of CBD to delta-1-THC and iso-THC

Boron trifluoride (BF3)- etherate on alumina

A one step reaction for CBD synthesis utilizes boron trifluoride (BF3)- etherate on alumina as condensing reagent in the reaction of (+)-e-mentha- diene-l-01 with olivetol on a 0.8mmol scale (refer to Figure 1). This results in CBD as the major product, with 55% yield as chromatographically pure oil or 41% yield as crystalline material. On a 100mmol scale, the yields were 46% as an oil, and 37% as crystalline material.

CBD Isolate API (Active Pharmaceutical Ingredient)

CBD Isolate API is a specific kind of CBD Isolate that is approved as an Active Pharmaceutical Ingredient (API). This means the whole production process is GMP certified and the CBD is suitable for use in pharmaceutical preparations.  CBD Oil Europe can only supply API Isolate via one of our partners to licensed companies outside the EU.

CBD Isolate API is used in the development of CBD based drugs, pharmaceutical applications, research, clinical studies, and clinical trials.

CBD Oil Europe is positioned to supply conventional CBD isolate throughout the European Union. We do consulting and sourcing GMP CBD only to certified buyers outside the EU. No health claims can be made on any of our CBD products.

CBD Oil Europe will immediately terminate any business relationship with an entity in case restrictions on health claims are violated.

API CBD Isolate 99.9% Pure Pharmaceutical Grade CBD Cannabidiol

Who is legally allowed to buy CBD API Isolate?

If you are a pharmaceutical company or medical research facility and have the necessary licences you can purchase CBD API Isolate directly from a number of manufacturers listed here:  Manufacturers and suppliers of Cannabidiol

Why is CBD API Isolate so Expensive?

Due to the limited supply and high cost of production API Isolate is up to 10 times more expensive than commodity grade CBD Isolate. All pharmaceutical grade ingredients are expensive by nature due to the rigorous demands of the Industry. The entire supply chain is GMP certified which ensures a consistency and safety and follows good manufacturing practice. The product is also shipped in a hermetically sealed packages and moved in refrigerated transport containers so you can be sure that it reaches you in pristine condition and maintains its GMP compliance records at all stages in the supply chain.


Where can I buy bulk CBD isolate in wholesale quantities?

We only give out wholesale pricing information to registered businesses who have been approved as customers. You can apply to become an approved customer here.
Please remember to include your VAT number when contacting us. You can talk to one of our experts who will discuss you needs and advise you the best CBD Isolate products that are legal in your country.

wholesale bulk CBD isolate 99% CBD Crystals

99% Pure CBD Crystals & Powder – Price Per KG

CBD Oil Europe offers competitive pricing on conventional CBD isolate. We service all business needs, with volume discounts from 100gr, 500gr, 1kg, 5kg and 10kg purchases. For orders above 10kg we require production planning not to exceed lead times.

Samples are available on request and are sent together with a recent COA. Our sample pack contains 10 grams of pure CBD isolate that gives you enough to make your own custom formulations, experiment with or send to an independent laboratory for testing. (Our sample pack is only available for B2B customers)

When to expect possible shortages of CBD isolate in 2019.


Buying CBD Isolate in larger quantities

If you are looking to buy large quantities of Isolate on a regular basis you need to be aware of the current production limitations in Europe and the yearly supply cycle. Many smaller producers will be out of stock come the summer as they wait for next years hemp harvest.

This can become a serious problem if you suddenly face a supply shortage.

With the explosive growth in interest regarding CBD and the influx of new players in the market we see this problem increasing in the near future. This is why it is wise to partner with a company that has access to multiple sources and not just a single supplier.

Based on data of previous years we expect the most pressure on supply of isolate from mid-august to December. Having said that, some developments in the Canadian and United States’ markets recently might see an inflow of speculative capital, possibly leading to buying up of stock in an effort to stifle competition.

Common applications and uses of CBD Isolate

Product Formulations using CBD Isolate

If you want to make product formulations using CBD Isolate you must fully understand the legalities which vary from country to country and for the type of product you intend to produce. We are happy to guide our clients through this process and answer any of your questions.

CBD Isolate for Cosmetics & Vape

CBD Isolate can legally be used in Cosmetics and Vape products.

CBD Isolate for food supplements

CBD Isolate added to food supplements takes them into the real of Novel Foods, which fall under a different set of EU regulations. Please check our blog post for more information on the EU Novel food regulations. CBD isolate is determined to be novel in food by the European Commission and therefore cannot be marketed in the EU as a food product without first receiving market authorisation under the Novel Food guidelines.

Creating a ZERO THC product.

CBD Isolate is often used in countries that adhere to a Zero THC policy when it comes to hemp products. If you want to make a Zero THC product that contains botanically derived Cannabidiol you need to use CBD isolate. All other CBD extracts and extraction methods will leave some trace of THC.

Is CBD Isolate water soluble?

CBD isolate is oil soluble, it is NOT water soluble. It is commonly thought that isolate is water soluble, however this is not true. Because cannabinoids are soluble in fat, very lipid based oils are the best carriers of CBD. We recommend using Olive Oil, Hemp Seed Oil or MCT Oil.

How to consume pure isolate powder

Isolate Blended with a carrier oil

CBD isolate powder blends into any carrier oil like olive oil, hemp seed oil, coconut, palm, and avocado oils. The resulting blend can be used for the production of cosmetics and other topical products.

E-liquid blended with PG/VG for vaping CBD Isolate

CBD Isolate is a very popular ingredient for e-liquid (the liquid used in electronic cigarettes). The isolate is normally diluted with Propylene Glycol and mixed with Vegetable Glycerine. The resulting CBD e-liquid is hailed by it’s proponents as a less harmful alternative to tobacco, or as a method to stop smoking. These claims are at least partially backed up by scientific research.

Dabbing CBD Isolate with an E-nail

One of the quickest ways to consume CBD isolate is by dabbing. You will need a glass water pipe, a quartz nail attachment, a dabber to hold the CBD and a butane torch or electronic nail heating element (an e-nail). E-nails are more expensive, but much safer than using a butane torch for some users. Simply heat up the nail to 185º Celsius and place the CBD on it using the dabber while simultaneously inhaling off the water pipe. As soon as the CBD comes into contact with the hot nail, it vaporizes and can be inhaled after cooling.

Terpene infused cbd products

CBD Isolate allows you to create Zero THC blends with added terpenes. These kind of products are perfect for the French market and other Zero THC countries in Europe.  

  • The product is made from EU hemp strains.
  • That it’s made only from stems, stalks and seeds (not flowers)
  • That is 99,x% concentrated with no detectable trace of any THC on any COAs

CBD isolate powder can be mixed with a carrier oil and then hemp terpenes are added to produce a legal CBD oil with Zero THC.

What is the difference between CBD isolate and CBD oil?

CBD Isolate behaves differently than full spectrum CBD oil.  In fact, Dr David Dedi Meiri—molecular biologist and researcher from Israel’s esteemed Technion—says that research conducted in his Laboratory of Cannabinoid Research shows that in experiments that have added large doses of purified CBD to already effective small doses of CBD does not produce any further effect. These experiments reinforce the importance of the synergy between the combination of the terpenes, flavonoids, phytocannabinoids, and other plant compounds, i.e. the entourage effect.

Having said that, there are a wide variety of situations when CBD isolate would be preferred over Full Spectrum CBD. The most important question to answer whether you need an isolate or a full spectrum extract is the application and the legal requirements thereof. CBD isolate cannot be an ingredient in food supplements, but can be used in the formulation of cosmetics.

Isoterp or Terpsolate: How to boost the qualities of a CBD Isolate formulation while still remaining legal

There are ways to boost the qualities of CBD Isolate by re-introducing hemp terpenes which have been fractionated off in the manufacturing process. We call these kind of products, isoterps and terpsolate.

For example, linalool has been used as an antidepressant, sleep-aid, and an anti-convulsant.  Another terpene, caryophyllene, is a known antioxidant, antidepressant, and anti-inflammatory. When you add Terpenes you can also make certain medical claims compared to the current limitations on medical claims when marketing CBD (cannabidiol)

Isoterp: is a mixture of 99% pure CBD and terpenes in a carrier oil. This product contains Zero THC. Please contact us to discuss your specific formulation needs.

Terpsolate: is used to describe CBD isolates which have been combined with terpenes, most popularly used for dabbing,  These products offer a balanced combination of 99+% pure CBD isolate and hemp-derived terpenes, offering a satisfying dabbing experience.

Why buy EU certified CBD Isolate?

When looking for a CBD Isolate producer or supplier it’s important to consider where the CBD isolate in manufactured. If you purchase from a broker or dealer you may find the CBD Isolate originates in another country that has less stringent quality controls or has importation limitations.

The market for export cannabis products is restricted to highly regulated markets. Of these, Canada, Australia and Europe are the most attractive and accessible markets. These markets each have their own laws around the types of products allowed to be imported and sold.

Many US companies in legal states have an excess of CBD Isolate and nowhere to sell it since cannabis products are illegal federally. Brokers in this black markets offer prices below the current European norms. Be aware that importing any cannabis extract from the United States violates both US federal law and European law. The reason is that in the US, non-EU approved cultivars are used. These are illegal federally and are classified as illegal cannabis extracts in the EU.

In the best case, shipments can get held at customs and destroyed, in the worst case accompanied by monetary punishment and/or jail time.


international legal cannabis trade

China has a massive hemp industry, but their products are largely GMO and much of the product is contaminated with heavy metal and pollutants, making it unacceptable to global markets. 

Be especially vigilant for residual solvents, heavy metals and pesticides or other contaminants. Get your samples tested at one of our recommended laboratories that specialise in heavy metals and pesticide contaminants.

CBD Oil Europe are based in the Netherlands, perfectly positioned to supply CBD isolate anywhere inside the European Union or to other legal export countries. Contact us today for more information about buying CBD Isolate in bulk quantities